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ent-Labdane diterpenoids from Andrographis paniculata.

Yun-Heng Shen·Rong-Tao Li·Wei-Lie Xiao·Gang Xu·Zhong-Wen Lin·Qin-Shi Zhao·Han-Dong Sun
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Abstract

Six new ent-labdane diterpenoids, 3-O-beta-D-glucopyranosyl-14,19-dideoxyandrographolide (1), 14-deoxy-17-hydroxyandrographolide (2), 19-O-[beta-D-apiofuranosyl(1-->2)-beta-D-glucopyranoyl]-3,14-dideoxyandrographolide (3), 3-O-beta-d-glucopyranosylandrographolide (4), 12S-hydroxyandrographolide (5), and andrographatoside (6), together with 17 known analogues, were isolated from the aerial parts of Andrographis paniculata. The structures of 1-6 were determined by spectroscopic data analysis. All compounds isolated were evaluated for their inhibitory activity against several bacterial and fungal strains.

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AndrographisAnti-Bacterial AgentsBacillus subtilisDiterpenesDrugs, Chinese HerbalMolecular StructureNuclear Magnetic Resonance, BiomolecularPlants, MedicinalStereoisomerismJournal Article

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Yun-Heng Shen, Rong-Tao Li, Wei-Lie Xiao, Gang Xu, Zhong-Wen Lin, Qin-Shi Zhao, Han-Dong Sun. 2006. ent-Labdane diterpenoids from Andrographis paniculata.. https://doi.org/10.1021/np050160u

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