Cellular patterns of transcription factor expression in developing cortical interneurons.

Inma Cobos; Jason E Long; Myo T Thwin; John L Rubenstein

doi:10.1093/cercor/bhk003

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Cellular patterns of transcription factor expression in developing cortical interneurons.

Inma Cobos·Jason E Long·Myo T Thwin·John L Rubenstein

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Abstract

Most gamma-aminobutyric acidergic interneurons in the neocortex and hippocampus are derived from subpallial progenitors in the medial ganglionic eminence and migrate tangentially to the pallium, where they differentiate into a diverse set of neuronal subtypes. Toward elucidating the mechanisms underlying the generation of interneuron diversity, we have studied in mice the expression patterns in differentiating and mature neocortical interneurons of 8 transcription factors, including 6 homeobox (Dlx1, Dlx2, Dlx5, Arx, Lhx6, Cux2), 1 basic helix-loop-helix, (NPAS1), and 1 bZIP (MafB). Their patterns of expression change during interneuron differentiation and show distinct distributions within interneuron subpopulations in adult neocortex. This study is a first step to define the combinatorial codes of transcription factors that participate in regulating the specification and function of cortical interneuron subtypes.

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Aging Animals Body Patterning Cell Aggregation Cell Differentiation Cell Movement Gene Expression Regulation, Developmental In Vitro Techniques Interneurons Mice Mice, Knockout Neocortex Nerve Net Organogenesis Tissue Distribution Transcription Factors Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

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Inma Cobos, Jason E Long, Myo T Thwin, John L Rubenstein. 2006. Cellular patterns of transcription factor expression in developing cortical interneurons.. https://doi.org/10.1093/cercor%2Fbhk003

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