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Is it possible to develop pan-arthropod vaccines?

J Santiago Mejia·Jeanette V Bishop·Richard G Titus
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Abstract

Hematophagous arthropods that transmit the etiological agents of arthropod-borne diseases have become the focus of anti-vector vaccines, targeted mainly at components of their saliva and midgut. These efforts have been directed mostly towards developing species-specific vaccines. An alternative is to target cross-reactive epitopes that have been preserved during evolution of the arthropods. The N- and O-linked glycans that are attached to arthropod glycoproteins are one of the potential targets of this pan-arthropod vaccine approach. Here, we discuss how genetically modified Drosophila melanogaster cells can be used to synthesize and to deliver these arthropod glycans to vertebrate hosts.

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AnimalsArthropod VectorsArthropodsEpitopesHumansImmunologic FactorsInsect ProteinsSafetySalivaVaccinationVaccines, SubunitJournal ArticleResearch Support, N.I.H., ExtramuralReview

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BibTeXRIS

J Santiago Mejia, Jeanette V Bishop, Richard G Titus. 2006-06-19. Is it possible to develop pan-arthropod vaccines?. https://doi.org/10.1016/j.pt.2006.06.001

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