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Plan to be flexible: a commentary on adaptive designs.

Weichung Joe Shih
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Abstract

This is a discussion of the following three papers appearing in this special issue on adaptive designs: 'Nested repeated confidence intervals and switching between noninferiority and superiority' by Joachim Hartung and Guido Knapp; 'Confirmatory Seamless Phase II/III Clinical trials with Hypotheses Selection at Interim: General Concepts' by Frank Bretz, Heinz Schmidli, Franz König, Amy Racine and Willi Maurer; and 'Confirmatory Seamless Phase Il/III Clinical Trials with Hypotheses Selection at Interim: Applications and Practical Considerations' by Heinz Schmidli, Frank Bretz, Amy Racine and Willi Maurer.

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BiometryClinical Trials, Phase II as TopicClinical Trials, Phase III as TopicConfidence IntervalsData Interpretation, StatisticalModels, StatisticalResearch DesignSample SizeCommentJournal Article

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Weichung Joe Shih. 2006. Plan to be flexible: a commentary on adaptive designs.. https://doi.org/10.1002/bimj.200610241

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