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PubMed · 17055426

Do sigma factors need help with a meltdown?

Ruth M Saecker·Caroline A Davis·M T Record
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Abstract

In this issue of Cell, Hsu et al. (2006) report on the binding activity of a variant of the bacterial transcriptional specificity factor sigma (sigma) to promoter DNA. This study demonstrates that the sigma variant induces a large distortion in the transcriptional start site in the absence of core RNA polymerase, raising intriguing new questions about the roles of sigma and core RNA polymerase in transcription initiation.

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Bacillus subtilisBacterial ProteinsDNA, BacterialDNA-Directed RNA PolymerasesModels, GeneticNucleic Acid DenaturationPromoter Regions, GeneticSigma FactorTranscription Initiation SiteTranscription, GeneticCommentJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov't

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Ruth M Saecker, Caroline A Davis, M T Record. 2006-10-20. Do sigma factors need help with a meltdown?. https://doi.org/10.1016/j.cell.2006.10.009

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