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PubMed · 17091394

A flexible transcutaneous oxygen sensor using polymer membranes.

Hiroyuki Kudo·Shigehito Iguchi·Takua Yamada·Tatsuya Kawase·Hirokazu Saito·Kimio Otsuka·Kohji Mitsubayashi
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Abstract

A wearable and flexible oxygen sensor for transcutaneous blood gas monitoring was fabricated and tested. The sensor has a laminar film-like structure, which was fabricated by pouching KCl electrolyte solution by both non-permeable (metal weldable) sheet and gas-permeable membrane with Pt- and Ag/AgCl-electrodes patterned using microfabrication process. The electrolyte solution was fixed only by heat-sealing the edges of the weldable membranes without any chemical adhesives. The wearable oxygen sensor (thickness: 84 mum) was applied to the electrochemical measurement with a constant potential of -600 mV vs. Ag/AgCl, thus obtaining the calibration range to dissolved oxygen (DO) from 0.0 to 7.0 mg/l with a correlation coefficient of 0.998 and the quick response time (53.4 s to 90% of a steady-state current), which operate similarly to a commercially available oxygen electrode. The sensor was also utilized to transcutaneous oxygen monitoring for healthy human subject. The sensing region of the wearable oxygen sensor was attached onto the forearm-skin surface of the subject inhaling various concentrations of oxygen. As a result of physiological application, the output current was varied from -6.2 microA to -7.8 microA within 2 min when the concentration of inhaling oxygen was changed from atmospheric air to 60% oxygen. Thus, the transcutaneous oxygen was successfully monitored without any inconveniences such as skin inflammation, etc.

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Biosensing TechniquesElectrochemistryElectrodesEquipment DesignEquipment Failure AnalysisHumansMembranes, ArtificialMonitoring, AmbulatoryOximetryPolymersReproducibility of ResultsSensitivity and SpecificitySkinEvaluation StudyJournal Article

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Hiroyuki Kudo, Shigehito Iguchi, Takua Yamada, Tatsuya Kawase, Hirokazu Saito, Kimio Otsuka, Kohji Mitsubayashi. 2007. A flexible transcutaneous oxygen sensor using polymer membranes.. https://doi.org/10.1007/s10544-006-9000-z

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