Anticancer gelatin microspheres with multiple functions.

C H Yan; X W Li; X L Chen; D Q Wang; D C Zhong; T Z Tan; H Kitano

doi:10.1016/0142-9612(91)90109-n

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Anticancer gelatin microspheres with multiple functions.

C H Yan·X W Li·X L Chen·D Q Wang·D C Zhong·T Z Tan·H Kitano

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Abstract

Biodegradable, hydrophilic gelatin microspheres (GM) with an average diameter of 70 microns were prepared by cross-linking gelatin with glutaraldehyde for hepatic intra-arterial infusion. An anticancer agent, mitomycin C (MMC), together with a radioisotope, 131I, were bound to the GM for chemotherapy and local internal radiotherapy. The 131I-labelled MMC-GM (131I-MMC-GM) could accumulate in the specific site and embolize the hepatic arteries after the hepatic intra-arterial infusion, while it caused various effects to the liver cells. The 131I-MMC-GM remained within the hepatic arteries for at least one month. In vitro release of drugs from the GM was also quantified using a dynamic dialysis method.

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Animals Antineoplastic Agents Biocompatible Materials Dogs Drug Delivery Systems Gelatin Hepatic Artery Infusions, Intra-Arterial Iodine Radioisotopes Microspheres Mitomycin Journal Article Research Support, Non-U.S. Gov't

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C H Yan, X W Li, X L Chen, D Q Wang, D C Zhong, T Z Tan, H Kitano. 1991. Anticancer gelatin microspheres with multiple functions.. https://doi.org/10.1016/0142-9612(91)90109-n

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