[Experimental study on hydroxyapatite soaked in sodium fluoride--with special reference to bone formation].

T Nishino

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PubMed · 1787344

[Experimental study on hydroxyapatite soaked in sodium fluoride--with special reference to bone formation].

T Nishino

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Abstract

An experimental comparative study on bone formation regarding surface implantation was performed on thirty three adult mongrel dogs; using either a hydroxyapatite soaked in sodium fluoride (F-HAP) or a hydroxyapatite (HAP). F-HAP was made as follows: the HAP was soaked in 100ml of sodium fluoride solution of 5ppm., 10ppm. and 100ppm. concentration for an hour under vacuum deaeration+. Under general anesthesia, specimens were implanted into the bone immediately inferior to tibial tubercle by opening a window using a 3.5mm drill. Postoperative course was observed periodically (radiologically, macroscopically and histopathologically) from one to twelve weeks. There were no marked differences on X-rays or macroscopic findings between HAP and F-HAP. Histopathologically, there was significant new bone formation in the F-HAP specimens up until four weeks postoperatively. The 5ppm specimen especially indicated the most significant bone formation. The results of this study suggested that F-HAP was a better biomaterial (concerning new bone formation on the implant's surface) and that 5ppm was at optimal concentration for early new bone formation.

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Animals Dogs Hydroxyapatites Osseointegration Sodium Fluoride English Abstract Journal Article

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T Nishino. 1991. [Experimental study on hydroxyapatite soaked in sodium fluoride--with special reference to bone formation].. https://pubmed.ncbi.nlm.nih.gov/1787344/

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