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PubMed · 2160426

Effect of perchlorate on mitochondrial function.

K Vijayalakshmi·D B Motlag
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Abstract

Administration of sodium perchlorate to rats for 45 days leads to decreased activities of citric acid cycle enzymes. The oxidation of succinate both in state 3 and state 4 conditions and endogenous ATP content of mitochondria decreased during perchlorate toxicity. The significant decrease in cytochrome aa3 in perchlorate-treated rats may be one of the prime factors involved in the decreased rate of respiration. The permeability of mitochondria of perchlorate-treated rats is altered as indicated by increased oxidation of NADH and low respiratory control ratio (RCR).

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AnimalsKidneyMaleMitochondriaMitochondria, LiverPerchloratesRatsRats, Inbred StrainsJournal Article

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K Vijayalakshmi, D B Motlag. 1990. Effect of perchlorate on mitochondrial function.. https://pubmed.ncbi.nlm.nih.gov/2160426/

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