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Cutaneous malakoplakia simulating relapsing malignant lymphoma.

J P Palazzo·D J Ellison·I E Garcia·C Langer·R M Scher·J P Hoffman·R O Petersen
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Abstract

This report describes the case of a 42-year-old man with malignant lymphoma, diffuse large non-cleaved cell type, who developed cutaneous malakoplakia in the left groin. The patient had widespread lymph node involvement, including a left inguinal mass which was clinically thought to represent recurrent lymphoma. The inguinal mass failed to regress after chemotherapy and irradiation, although lymphoma in other sites responded to chemotherapy. A skin biopsy of the area showed an ulcer and an abscess involving the dermis and subcutaneous tissue. Microscopically, a diffuse infiltrate of foamy histiocytes was seen with numerous intracellular and extracellular, round and laminated bodies. Some of these bodies had a "targetoid" appearance, stained strongly with von-Kossa's calcium stain and showed the typical appearance of Michaelis-Gutmann bodies by electron microscopy. Cultured monocytes from the peripheral blood of the patient showed ultrastructural features similar to their tissue counterparts, suggesting a systemic involvement of the monocyte macrophage lineage. This case represents an unusual presentation of malakoplakia of the skin associated with relapsing malignant lymphoma in a patient on immunosuppressive drugs.

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AdultGroinHead and Neck NeoplasmsHistiocytesHumansInclusion BodiesLymphatic MetastasisLymphomaMalacoplakiaMaleNeoplasm Recurrence, LocalCase ReportsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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J P Palazzo, D J Ellison, I E Garcia, C Langer, R M Scher, J P Hoffman, R O Petersen. 1990. Cutaneous malakoplakia simulating relapsing malignant lymphoma.. https://doi.org/10.1111/j.1600-0560.1990.tb00077.x

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