Right-left ventricular balance in implanted electrically powered artificial hearts.

J W Long; P Khanwilkar; K R Crump; G M Pantalos; M Kinoshita; H C Kim; D B Olsen

PubMed · 2252680

Right-left ventricular balance in implanted electrically powered artificial hearts.

J W Long·P Khanwilkar·K R Crump·G M Pantalos·M Kinoshita·H C Kim·D B Olsen

Abstract

An electrohydraulic total artificial heart (EHTAH), using an interatrial shunt (IAS) for right-left heart balance, was evaluated in acute, in vivo, open-chested calves. The EHTAH system demonstrated physiologic autoregulation with Starling-like responsiveness to preload. Output varied from 4 to 9 L/min, as right atrial pressure increased from 3 to 15 mmHg. Device output was minimally influenced by afterload. The efficacy of an IAS to balance the EHTAH was demonstrated over a wide range of preload and afterload conditions. Interatrial shunt flow rates, reflective of the degree of right-left imbalance, varied from 2% to 14% (IAS flow from left to right) of cardiac output. Left atrial pressures typically did not exceed right atrial pressures by more than 6-8 mmHg using an instrumented vascular graft such as the IAS. The simplicity and distinct anatomic, surgical, and engineering advantages of the IAS approach to right-left balance of implanted electrically powered artificial hearts justify further development toward a reliable long-term design.

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J W Long, P Khanwilkar, K R Crump, G M Pantalos, M Kinoshita, H C Kim, D B Olsen. Right-left ventricular balance in implanted electrically powered artificial hearts.. https://pubmed.ncbi.nlm.nih.gov/2252680/

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