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Normotensive renal failure in systemic sclerosis.

D J Helfrich·B Banner·V D Steen·T A Medsger
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Abstract

Of 140 patients with "scleroderma renal crisis" encountered during a 33-year period, 15 of 131 (11%) whose blood pressures were recorded were normotensive during this complication. In comparison with 116 patients with hypertension, the normotensive patients significantly more often had microangiopathic hemolytic anemia (90% versus 38%) and thrombocytopenia (83% versus 21%). Pulmonary hemorrhage occurred in 6 normotensive patients. More normotensive patients had received high doses of corticosteroids (prednisone greater than or equal to 30 mg/day) during the 2 months immediately preceding renal crisis (64% versus 16%). A role for corticosteroids in precipitating renal crisis is suggested. The 12-month survival was significantly reduced in the normotensive patients (13% versus 35%).

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Acute Kidney InjuryBlood PressureHumansHypertensionKidneyPrednisoneProspective StudiesRetrospective StudiesScleroderma, SystemicSkinComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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D J Helfrich, B Banner, V D Steen, T A Medsger. 1989. Normotensive renal failure in systemic sclerosis.. https://doi.org/10.1002/anr.1780320911

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