Buoyant sustained release tablets based on chitosan.

K Inouye; Y Machida; T Sannan; T Nagai

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PubMed · 2855572

Buoyant sustained release tablets based on chitosan.

K Inouye·Y Machida·T Sannan·T Nagai

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Abstract

This study attempted to develop sustained release intragastric 'floating' tablets based on chitosan. Two kinds of chitosan with different degrees of deacetylation (chitosan H and L) were used, and two types of preparations (types A and B) were examined. Type A preparations, i.e. directly compressed tablets using a mixture of sodium hydrogen carbonate and citric acid, were buoyant immediately and gave sustained release of prednisolone (as model drug) in acidic dissolution fluid. Type B preparations, i.e. preparations composed of a directly compressed layer and a chitosan H membrane layer enclosing carbon dioxide (a foamy membrane layer), quickly developed buoyancy and also provided sustained release of drug. The drug release rate from the preparation using chitosan L was slower than that from the preparation using chitosan H. In an absorption study using beagle dogs, sustained drug absorption from Type B preparations was obtained.

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Animals Bicarbonates Chelating Agents Chitin Chitosan Citrates Citric Acid Dogs Drug Design Male Prednisolone Sodium Sodium Bicarbonate Solubility Tablets, Enteric-Coated Comparative Study Journal Article

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K Inouye, Y Machida, T Sannan, T Nagai. 1988. Buoyant sustained release tablets based on chitosan.. https://pubmed.ncbi.nlm.nih.gov/2855572/

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