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Structure, sequence and polymorphism in the HLA-D region.

J Trowsdale·J A Young·A P Kelly·P J Austin·S Carson·H Meunier·A So·H A Erlich·R S Spielman·J Bodmer
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Abstract

Molecular analysis of the HLA-D region has uncovered a complex array of related genes encompassing a minimum of 6 alpha and 7 beta chain sequences. A high level of polymorphism is characteristic of the DQ alpha and beta genes, as well as DR beta. The DP genes, both alpha and beta, are also polymorphic, though to a lesser extent. The genes fit into the previously established loci: DP, DQ and DR, except for a newly-discovered sequence, DZ alpha, which is approximately equally related to all of the other alpha chain genes. Analysis of the polymorphism and evolution of the HLA-D region, by examination of the sequences, calls for several independent duplication events in the generation of this family of genes.

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Base SequenceBiological EvolutionChromosome MappingCloning, MolecularCosmidsDNADNA Restriction EnzymesHLA-DP AntigensHLA-DQ AntigensHLA-DR AntigensHistocompatibility Antigens Class IIHumansMolecular ConformationPolymorphism, GeneticTransfectionComparative StudyJournal ArticleReview

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J Trowsdale, J A Young, A P Kelly, P J Austin, S Carson, H Meunier, A So, H A Erlich, R S Spielman, J Bodmer. 1985. Structure, sequence and polymorphism in the HLA-D region.. https://doi.org/10.1111/j.1600-065x.1985.tb01129.x

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