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PubMed · 3246611

Simple multi-process data sharing with the VAX/VMS operation system.

S D Davilla·P Ingram·A LeFurgey·M K Lamvik
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ComputersElectronic Data ProcessingMinicomputersJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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S D Davilla, P Ingram, A LeFurgey, M K Lamvik. 1988. Simple multi-process data sharing with the VAX/VMS operation system.. https://doi.org/10.1002/jemt.1060080212

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Molecular orbital study on the glutathione-dependent detoxication of ozonides.

The present paper describes a theoretical study on the mechanism underlying the reaction of cellular glutathione (GSH) with polyunsaturated fatty acid ozonides. The reaction can be catalyzed by glutathione S-transferases and leads to detoxication of the ozonides. Semi-empirical molecular orbital computer calculations suggest that the reaction of glutathione with ozonides involves a nucleophilic attack at one of the carbon atoms of the ozonide ring, instead of at one of the peroxidic oxygen atoms of the ozonide ring. This implies a mechanism different from that of the glutathione S-transferase-mediated reaction with hydroperoxides, previously proposed for the glutathione-dependent detoxication of fatty acid ozonides.

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