Comparative evaluation of six techniques for determining the Michaelis-Menten parameters relating phenytoin dose and steady-state serum concentrations.

P W Mullen; R W Foster

doi:10.1111/j.2042-7158.1979.tb13441.x

Home/Archive/PubMed

PubMed · 33239

Comparative evaluation of six techniques for determining the Michaelis-Menten parameters relating phenytoin dose and steady-state serum concentrations.

P W Mullen·R W Foster

View original source ↗Export metadata ↓

Abstract

Using randomly generated data within set error limits, the Michaelis-Menten parameters Dmax and Km relating steady-state serum phenytoin concentrations (Css) and dose (D) were determined by 5 graphical techniques and an iterative computer fit to the hyperbolic equation. The best mean estimates of Dmax and Km were provided by the latter. Assuming the experimental error to be in Css the results indicate that the most reliable graphical technique is that based on the equation Css = Dmax Css/D - Km. However, considering its obvious simplicity and relative reliability the direct linear plot is recommended for clinical use.

Explore related subjects

Computers Dose-Response Relationship, Drug Humans Kinetics Mathematics Methods Models, Biological Phenytoin Comparative Study Journal Article

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

P W Mullen, R W Foster. 1979. Comparative evaluation of six techniques for determining the Michaelis-Menten parameters relating phenytoin dose and steady-state serum concentrations.. https://doi.org/10.1111/j.2042-7158.1979.tb13441.x

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Evaluation of sites for the location of WEEE recycling plants in Spain.

As a consequence of new European legal regulations for treatment of waste electrical and electronic equipment (WEEE), recycling plants have to be installed in Spain. In this context, this contribution describes a method for ranking of Spanish municipalities according to their appropriateness for the installation of these plants. In order to rank the alternatives, the discrete multi-criteria decision method PROMETHEE (Preference Ranking Organisation METHod for Enrichment Evaluations), combined with a surveys of experts, is applied. As existing plants are located in North and East Spain, a significant concentration of top ranking municipalities can be observed in South and Central Spain. The method does not present an optimal structure of the future recycling system, but provides a selection of good alternatives for potential locations of recycling plants.

Computers↗

PubMed2007

Digital images of case reports and other articles.

Explore the source record for details and available documents.

Computers↗

PubMed2007

Overview of informatics for high content screening.

With the growing use of high content screening (HCS) and analysis in drug discovery and systems biology, informatics has come to the forefront as a critical technology to effectively utilize the massive volumes of high content data and images being generated. Informatics technologies are required to transform HCS data and images into useful information and then into knowledge to drive decision making in an efficient and cost effective manner. In this chapter, we provide an overview of informatics tools and technologies for HCS, discuss some of the challenges of harnessing the huge and growing volumes of HCS data, and provide insight to help toward implementing or selecting, and utilizing a high content informatics solution to meet your organization's needs.

Computers↗