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PubMed · 3427169

A two-stage procedure for bioequivalence studies.

A Racine-Poon·A P Grieve·H Flühler·A F Smith
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Abstract

A two-stage experimental procedure for bioequivalence studies is proposed. The procedure is based on the idea that information from a first-stage experiment can be used to form a predictive distribution for the outcome of a second-stage experiment, thus permitting an assessment of the probability of a successful overall outcome. A systematic numerical study of a variety of possible strategies results in the identification of procedures that lead to substantial increases in efficiency compared with single-stage studies.

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BiometryClinical Trials as TopicHumansProbabilityResearch DesignTherapeutic EquivalencyComparative StudyJournal Article

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A Racine-Poon, A P Grieve, H Flühler, A F Smith. 1987. A two-stage procedure for bioequivalence studies.. https://pubmed.ncbi.nlm.nih.gov/3427169/

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