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A demonstration of pharmacokinetics and physiological modelling using a microcomputer for data capture and analysis.

L Kirkup·D J Nichols·J Sutherland
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Abstract

We describe a simple and inexpensive demonstration of mass transport and exchange using dye clearance from a hydrodynamic model. A microcomputer was used for data acquisition and storage, non-linear least squares curve fitting, compartmental analysis and parameter estimation. The system is useful for demonstrating the indicator-dilution technique for fluid volume measurement and compartmental analysis in pharmacokinetics.

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AlgorithmsBiological TransportComputersMathematical ComputingMicrocomputersModels, BiologicalPharmacokineticsSoftwareJournal Article

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L Kirkup, D J Nichols, J Sutherland. 1986. A demonstration of pharmacokinetics and physiological modelling using a microcomputer for data capture and analysis.. https://doi.org/10.1093/bioinformatics%2F2.4.277

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