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PubMed · 34736

Meningitis from a pneumococcus moderately resistant to penicillin.

J C Gartner·R H Michaels
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Abstract

Strains of pneumococci moderately resistant to penicillin were recovered from three patients at the Children's Hospital of Pittsburgh during 1978. One of these children had meningitis and showed signs of early relapse despite high doses of penicillin G potassium. Routine screening of pneumococci for penicillin resistance is recommended.

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ChloramphenicolErythromycinHumansInfantMaleMeningitis, PneumococcalPenicillin GPenicillin ResistancePennsylvaniaStreptococcus pneumoniaeCase ReportsJournal Article

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J C Gartner, R H Michaels. 1979-04-20. Meningitis from a pneumococcus moderately resistant to penicillin.. https://pubmed.ncbi.nlm.nih.gov/34736/

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Chloramphenicol↗
PubMed1979

In vivo methylation of prokaryotic elongation factor Tu.

In Salmonella typhimurium and Escherichia coli, elongation factor Tu (EF-Tu) is methylated as shown by its incorporation of labeled methyl residues from [methyl-3H]methionine. Analysis of the nature of the methyl-containing residues by protein hydrolysis, followed by paper chromatography and high voltage electrophoresis showed that both mono- and dimethyllysine are present. Eighty per cent of the EF-Tu molecules are methylated if methylation occurs at a unique lysine residue. The EF-Tu fraction which is not methylated is still able to accept methyl groups, as shown by methylation of approximately 10% of the EF-Tu after addition of chloramphenicol (D-(-)-threo-2,2-dichloro-N-[beta-hydroxy-alpha-(hydroxymethyl)-o-nitrophenethyl] acetamide) to inhibit further protein synthesis. There is no evidence of turnover of the methyl residues. We attempted to separate the methylated from the nonmethylated form of EF-Tu by isoelectric focusing on polyacrylamide gel, but were unable to do so.

Chloramphenicol↗