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PubMed · 3557684

Biofiltration with buffer-free dialysate.

U Buoncristiani·M Ragaiolo·V Petrucci·F Bruni·E Pala·C Damiani·R Brugnano
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Abstract

The presence of acetate in the dialysate appears to be superfluous in the new depurative technique indicated as biofiltration, which consists in a standard hemodialysis with high ultrafiltration combined with the reinfusion of 3-4 1/2 liters of solution containing bicarbonate. The presence of acetate could in fact be contraindicated by a number of potential side effects, metabolic, cardiovascular and biological. Hence, starting from the consideration that in standard biofiltration a buffer is already infused directly as bicarbonate, we tried to overcome the potential hazards of the acetate-containing bath simply by using a dialysate without acetate and by increasing the concentration of bicarbonate in the reinfusate. A cumulative clinical experience of 20 months in 4 patients proved the feasibility and safety of the technique and suggests further advantages over standard biofiltration (better control of acid-base equilibrium, better cardiovascular stability.

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AcetatesAdultBicarbonatesBloodBuffersFemaleHemodynamicsHumansMaleMiddle AgedOsmolar ConcentrationRenal DialysisRheologySodiumUltrafiltrationJournal Article

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U Buoncristiani, M Ragaiolo, V Petrucci, F Bruni, E Pala, C Damiani, R Brugnano. 1986. Biofiltration with buffer-free dialysate.. https://pubmed.ncbi.nlm.nih.gov/3557684/

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