Methotrexate neuroenteropathy--a histochemical study.

M G el-Badawi; J A Fatani; M A Qayyum

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PubMed · 3662027

Methotrexate neuroenteropathy--a histochemical study.

M G el-Badawi·J A Fatani·M A Qayyum

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Abstract

10 mg/kg Methotrexate was injected daily for 5 d a week for a total period of 3 weeks and its effect on autonomic nerve profiles of jejunum was studied using histochemical methods. Initially (after 5 doses in a week) partial degeneration of adrenergic and cholinergic nerve supply was observed. Prolonged treatment (15 does in 3 weeks) was responsible for disappearance of about 30% of adrenergic and 50% of cholinergic nerve profiles. Early degenerative changes in the cholinergic nerve cells of the intestinal plexuses was also noted.

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Acetylcholinesterase Adrenergic Fibers Animals Autonomic Nervous System Cholinergic Fibers Injections, Intraperitoneal Jejunum Methotrexate Microscopy, Fluorescence Nerve Degeneration Journal Article Research Support, Non-U.S. Gov't

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M G el-Badawi, J A Fatani, M A Qayyum. 1987. Methotrexate neuroenteropathy--a histochemical study.. https://pubmed.ncbi.nlm.nih.gov/3662027/

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