PubMed · 3809182
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T Niijima, L Denis, E Pontes, O Alfthan, H Akaza, N Jaeger, T Kotake, Y Ohi, M Fujime. 1986. Diagnostic work-up.. https://pubmed.ncbi.nlm.nih.gov/3809182/
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Pap smears obtained with Ayre spatula and cytobrush by four experienced private practice gynecologists were submitted to the cytology laboratory on either two slides or one slide. For each physician, 500 consecutive cases were studied for each of 4 consecutive years. Compared to the first 2 years (double-slide cases), the rates of abnormal smears increased from 4.28 to 5.58% while the number of unsatisfactory smears decreased from 1.83 to 0.98% for the years with all single-slide cases. These changes were not statistically significant. Follow-up biopsy findings were not different between the groups. Similar findings were seen when the medical community that submits smears to this laboratory began to use primarily a single-slide technique. The daily screening workload in the laboratory decreased 29% as mostly one-slide smears were submitted despite an increase of 10% in the number of cases. The double-slide method for Pap smears can be safely replaced by a single-slide method.
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The aim of this study was to investigate whether the AgNOR technique could be helpful for the cytologic diagnosis of neoplastic and non-neoplastic urinary tract lesions. We analysed the AgNOR pattern in urinary cytology in samples from 70 patients. In every case the average number of silver precipitations per nucleus was counted and the range between the minimum and maximum AgNOR value calculated. Furthermore we noted whether the AgNOR precipitations had a homogeneous or heterogeneous distribution. The diseases were classified in three groups: non-neoplastic lesions, low grade and high grade carcinoma. Linear discriminant analysis (with jack-knife procedure) was performed with the AgNOR parameters as independent variables. The final diagnosis of each patient had been established by histological analysis of bladder biopsies. We obtained a correct classification in 84.3% of the cases. All patients with normal or reactive lesions were correctly classified and only two cases of low grade malignancy were erroneously diagnosed as non-malignant. Five high grade neoplasms had been classified as low grade and four low grade carcinomas had been over-diagnosed as high grade neoplasms. We conclude that a combined qualitative and quantitative AgNOR analysis can be useful in the differential diagnosis of urinary cytology.