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PubMed · 3859054

HLA polymorphisms in Nigerians.

R C Okoye·E Williams·A Alonso·P Doyle·J Awad·C Navarrete·D Jaraquemada·W E Ollier·H Festenstein
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Abstract

The HLA class I and class II phenotypes of a panel of 114 unrelated Nigerians have been determined. The panel was tested for all the known class I antigens and comparisons of the HLA-A and -B frequencies with those of other African Negroid populations revealed some differences. Only limited comparisons could be made for the HLA-DR and -D frequencies as these are not available for any well-defined African Negroid population. The data concerning the class II antigens of this panel are the most interesting. Half of the DRw11-positive panel members are DQw3 negative and DQw1 positive. In addition, there is dissociation of some HLA-D and -DR specificities, a number of panel members are positive for an HLA-D specificity and are negative for the corresponding HLA-DR specificity. Our results show the value of population studies in the investigation of the relationship between the different HLA class II antigens.

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Black PeopleGene FrequencyGenetic LinkageHLA AntigensHistocompatibility Antigens Class IIHumansNigeriaPolymorphism, GeneticWhite PeopleJournal ArticleResearch Support, Non-U.S. Gov't

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R C Okoye, E Williams, A Alonso, P Doyle, J Awad, C Navarrete, D Jaraquemada, W E Ollier, H Festenstein. 1985. HLA polymorphisms in Nigerians.. https://doi.org/10.1111/j.1399-0039.1985.tb00429.x

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