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PubMed · 3885013

[Chemotaxis defect and recurrent E. coli meningitis].

B Herpertz·S E Burdach·M Rister
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Abstract

The increased susceptibility to bacterial infections due to a decreased chemotaxis of neutrophil granulocytes was investigated in a premature small for gestational age baby, who such suffered from recurrent E. coli-meningitis. Causes as anatomic lesions, brain abscess, septic granuloumatosus disease and the Chédiak-Higashi-anomaly were ruled out. At the age of 9 and 13 weeks chemotaxis function compared to age-matched and adult controls was diminished. Addition of serum from healthy adults increased directed migration without reaching normal levels. The study of the complement status revealed a diminution of CH50, the alternate pathway components and C6-C9. Thus, decreased chemotaxis is believed to originate from a combined intrinsic-extrinsic defect. No relapses of infection were observed during prophylactic treatment with ascorbate and cotrimoxazole. Intrinsic as well as extrinsic chemotaxis became normal at the age of 7 months. Simultaneously, complement status was found to approach normal levels. The relevance of haematologic-immunologic evaluation in cases of relapsing severe bacterial infections in preterm newborns is discussed.

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Chemotaxis, LeukocyteComplement Pathway, AlternativeComplement System ProteinsEscherichia coli InfectionsFollow-Up StudiesGranulocytesHumansImmunoglobulinsImmunologic Deficiency SyndromesInfantInfant, NewbornInfant, Premature, DiseasesLeukocyte CountLeukocytosisMaleMeningitisRecurrenceSepsisCase ReportsEnglish AbstractJournal ArticleResearch Support, Non-U.S. Gov't

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B Herpertz, S E Burdach, M Rister. 1985. [Chemotaxis defect and recurrent E. coli meningitis].. https://pubmed.ncbi.nlm.nih.gov/3885013/

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