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Preformulation studies in a drug development program for tablet formulations.

C Graffner·M E Johansson·M Nicklasson·H Nyqvist
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Abstract

Recently developed techniques were applied in a preformulation program to select a compound and a suitable salt for use in a one-month toxicological test. The program showed that valuable information can be obtained prior to the choice of a compound as a candidate for a solid-dosage form. Information about the physical and mechanical properties of the chosen compound can be obtained with a limited amount of substance, i.e., surface color and hygroscopicity (1-2 g), dissolution rate and solubility (1-2 g), powder properties (1-2 g), and compaction properties (5-7 g).

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Chemical PhenomenaChemistry, PharmaceuticalChemistry, PhysicalColorDrug CompoundingDrug StabilityParticle SizePowdersSolubilityTabletsJournal Article

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C Graffner, M E Johansson, M Nicklasson, H Nyqvist. 1985. Preformulation studies in a drug development program for tablet formulations.. https://doi.org/10.1002/jps.2600740105

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