PubMed · 413804
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H D Bolte. 1977. [Pharmacologic testing of heart function].. https://pubmed.ncbi.nlm.nih.gov/413804/
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We found colocalization of renin, angiotensin (Ang) I and Ang II in juxtaglomerular (JG) cells of the kidney. Coexistence of Ang II in renin granules was demonstrated by electron microscopic immunogold labeling of these components. Coexistence of both Ang I and Ang II in the high density renin storage granules were also demonstrated by gradient centrifugation of renal homogenate. These findings supported the synthesis of Ang I and Ang II in juxtaglomerular cells. Isolated and cultured JG cells showed the synthesis of Ang I, Ang II and renin. Ang I and Ang II were secreted from isolated and perfused rat kidneys at steady rates over 2 hr. Their secretion rates were proportional to that of renin. The rate of Ang II secretion from the kidney was higher than that from the vascular bed. Ang II was also found in renal lymph. These findings indicate that a large amount of Ang II is generated in JG cells by the intracellular action of renin and may play a significant role in the regulation of renal function.
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We investigated the influence of cardiac arrest upon the metabolic function of the lungs, especially on prostaglandins and angiotensin in pulmonary arterial and venous blood (PA, PV) in dogs resuscitated after cardiac arrest. Experiments were performed on 36 dogs. Cardiac arrest was produced with the electric ventricular fibrillation. The resuscitation was carried out with 100% oxygen using a ventilator. Open chest cardiac massage was performed and defibrillation was done with DC of 25-75 W.sec. Epinephrine and 7% sodium carbonate were administered. Experimental groups were as follow; Group 1 (G I): CPR 5 minutes after the cardiac arrest. Group 2 (G II): CPR 10 minutes after the cardiac arrest. There were no significant differences between G I and G II in hemodynamics and blood gas. AT I was higher in PA than in PV, and AT II showed no significant difference between PA and PV. PGE2 and PGF2 alpha showed no significant changes in G I. And in G II they reached the peak in PA after resuscitation, PGE2 increased in PV, and PGF2 alpha showed no significant changes in PV. TXB2 and 6-keto-PGF1 alpha showed no differences between PA and PV, and they reached a peak after resuscitation in G II.