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PubMed · 4372635

Type C viral expression in primate tissues.

C J Sherr·R E Benveniste·G J Todaro
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Abstract

Nucleic acid sequences homologous to a [(3)H]DNA transcript prepared from an endogenous baboon type C virus are readily detected in both the cellular DNA and RNA of several different Old World monkeys. Competitive radioimmunoassays for the major viral protein (p30) of baboon type C viruses detect viral antigen in a normal stumptail spleen and a rhesus ovarian carcinoma. The p30 antigen from these tissues is closely related by several immunologic criteria to the p30 protein of baboon type C viruses. The results indicate that normal primate tissues transcribe endogenous viral-specific RNA and translate at least one viral structural protein.

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AnimalsDNA, ViralFemaleHaplorhiniMacacaNeoplasms, ExperimentalNucleic Acid HybridizationOvarian NeoplasmsPapioRNA, ViralRadioimmunoassayRetroviridaeSpleenTranscription, GeneticTritiumViral ProteinsJournal Article

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C J Sherr, R E Benveniste, G J Todaro. 1974. Type C viral expression in primate tissues.. https://doi.org/10.1073/pnas.71.9.3721

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