PubMed · 4715473
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E D Joseph. 1973. Aggression redefined--its adaptational aspects.. https://pubmed.ncbi.nlm.nih.gov/4715473/
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We present the first genome-wide study of recent evolution in Culex pipiens species complex focusing on the genomic extent, functional targets and likely causes of global and local adaptations. We resequenced pooled samples of six populations of C. pipiens and two populations of the outgroup Culex torrentium. We used principal component analysis to systematically study differential natural selection across populations and developed a phylogenetic scanning method to analyse admixture without haplotype data. We found evidence for the prominent role of geographical distribution in shaping population structure and specifying patterns of genomic selection. Multiple adaptive events, involving genes implicated with autogeny, diapause and insecticide resistance were limited to specific populations. We estimate that about 5-20% of the genes (including several histone genes) and almost half of the annotated pathways were undergoing selective sweeps in each population. The high occurrence of sweeps in non-genic regions and in chromatin remodelling genes indicated the adaptive importance of gene expression changes. We hypothesize that global adaptive processes in the C. pipiens complex are potentially associated with South to North range expansion, requiring adjustments in chromatin conformation. Strong local signature of adaptation and emergence of hybrid bridge vectors necessitate genomic assessment of populations before specifying control agents.
How brains have evolved in response to particular selection pressures is illuminated by ecological correlates of differences in brain structure among contemporary species. The focus of most comparative studies has been on the overall size of brains relative to body size, hence ignoring the ways in which selection operates on specific neural systems. Here we investigate evolutionary radiations in the size of visual and olfactory brain structures within three orders of mammals: primates, bats and insectivores. The comparative relationships within these three orders show both similarities and differences. After removal of the allometric effect of overall brain size, the sizes of different structures within each sensory modality are positively correlated in all three orders. Correlations between visual and olfactory structures, however, are negative in primates, negative but non-significant in insectivores, and positive in bats. In both primates and insectivores, nocturnal lineages tend to have larger olfactory structures than do diurnal or partly diurnal lineages, and among the primates diurnal lineages have larger striate visual cortexes. Hence the apparent trade-off between vision and olfaction in primates seems to be related to the divergence of nocturnal and diurnal forms. However, negative correlations between visual and olfactory structures were also found when nocturnal strepsirhines and diurnal haplorhines were analysed separately, suggesting that ecological variables in addition to activity timing may be significant. Indeed, there were also associations with diet: frugivory was associated with enlargements of the geniculostriate visual system in diurnal primates, enlargements of olfactory structures in nocturnal primates, and possibly enlargements of both in bats. Further ecological associations were found within insectivores: aquatic lineages had smaller olfactory structures than in their non-aquatic counterparts, and fossorial lineages had smaller optic nerves than in non-fossorial forms. We conclude that activity timing, diet and habitat have each played a role in the evolutionary radiation of mammalian sensory systems, but with varying effects in the different taxa. Some of the associations between ecology and sensory systems suggest alternative explanations for correlates of overall brain size, which have in the past commonly been interpreted in terms of selection on intelligence.
The intent of this study was to assess the effects of continued laboratory subculturing on selected biochemical properties of oral streptococci freshly isolated from dental plaque. Six fresh isolates (3 Streptococcus mutans and 3 non-mutans) and 2 laboratory strains were subcultured daily for a total of 225 transfers, and cells were harvested every 75 transfers from duplicate batch cultures grown with glucose at a constant pH. Eleven biochemical properties were assayed with cells, membranes and cell-free extracts and the results subjected to statistical analysis for differences between the duplicate cultures and the various subcultures. In addition, the activity of 19 hydrolytic enzymes was assayed with the semiquantitative apiZYM system (Analytab products). The activity of zero-time samples varied by as much as 241-fold for a single property with particularly low activity for EIIglc of the phosphoenolpyruvate phosphotransferase system and cell-associated extracellular polysaccharide synthesis. The 3 S. mutans fresh isolates had higher activity in 8 of the 11 assays compared with the 3 non-mutans strains, with extracellular polysaccharide synthesis the most significant trait. Statistical analysis of the 2816 assays of the 11 traits for the 8 test strains at the 4 selected time intervals revealed considerable change in the activity of the test parameters. The most notable changes in the S. mutans strains over the 225 subcultures were significant increases in glycolytic activity and decreases in hydrophobicity and extracellular polysaccharide synthesis activity. Of the measured properties, lactate dehydrogenase and cell-associated extracellular polysaccharide synthesis activity were the most stable and H+/ATPase activity was the most variable.(ABSTRACT TRUNCATED AT 250 WORDS)