PubMed · 507772
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
E L Spierings. 1979. Endogenous pain control mechanisms.. https://doi.org/10.1002/ana.410060131
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Normal human subjects grasped an isometric handle with an unrestrained, pronated hand. They were asked to exert forces continuously to draw lemniscates (figure eights) in specified or self-chosen planes and in the presence or absence of a three-dimensional visual feedback cursor and a visual template. In every condition, the mean plane orientation in the force space differed appreciably between the two loops of the figure, as described previously by Soechting and Terzuolo (1987a) for free drawing arm movements. These findings suggest that the planar segmentation of the motor trajectory is not a consequence of joint motion but arises from central constraints related to the production of motor trajectory in space.
"Reminders" (timely notices about specific clinical events to physicians or patients) are useful strategies for implementing clinical guidelines. These systems can vary widely in content, design, and purpose. This variability makes it difficult to compare systems or predict a reminder's efficacy in a particular setting. In this article, the authors suggest that too much attention has been paid to proving the efficacy of reminder systems as a general strategy or a comprehensive solution. Rather, the usefulness and effectiveness of reminder systems will be better appreciated when quality management principles are applied to designing, implementing, and maintaining them. Physicians must participate in finding the best solutions for clinical process problems, and reminder systems--when implemented as the "best solution"--must be monitored and improved continually on an ongoing basis to continue to meet physicians' needs.
There are interferences between function of the thyroid gland and the ovary. Thus, thyroid disorders may influence the ovarian cycle. Up to now interferences in three main areas are described: the secretion of GnRH, i.e. FSH and, above all, LH, the peripheral metabolism of steroids (androgens, estrogens, and SHBG), and metabolism of prolactin. By employing human luteal cells, we were able to demonstrate that there is also a direct impact of thyroid regulation on luteal function: TSH, but not TRH or T3 or T4, possesses a luteotropic activity and reaches one fifth of the biological activity of hCG. This kind or direct influence may play an important role in the pathophysiology in patients with hypothyroidism.