Relation between plasma lignocaine levels and induced haemodynamic changes.

P F Binnion; G Murtagh; A M Pollock; E Fletcher

doi:10.1136/bmj.3.5667.390

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Relation between plasma lignocaine levels and induced haemodynamic changes.

P F Binnion·G Murtagh·A M Pollock·E Fletcher

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Abstract

Intravenous lignocaine (1 mg./kg. body weight) was found to produce insignificant haemodynamic changes, and in particular no reduction in myocardial contractility. A rate of 2 mg./minute infused intravenously is suggested for therapeutic purposes.In anaesthetized dogs an infusion of 13.5 mg./minute caused moderate haemodynamic depression and a maximum plasma level of 7 mug./ml. Massive injections of 200 and 400 mg. of lignocaine produced a maximum plasma level of 13.8 and 27.8 mug./ml., respectively, and in the latter failure of myocardial contraction in the presence of a normal E.C.G. ensued ("pump failure"). Lignocaine appears to alter the uptake of calcium by myocardial sarcoplasmic reticulum, and this may explain the negative inotropic effect of large doses.

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Animals Arrhythmias, Cardiac Calcium Cardiac Output Cardiac Volume Dogs Electrocardiography Heart Heart Rate Humans Infusions, Parenteral Lidocaine Myocardial Infarction Myocardium Journal Article

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P F Binnion, G Murtagh, A M Pollock, E Fletcher. 1969-08-16. Relation between plasma lignocaine levels and induced haemodynamic changes.. https://doi.org/10.1136/bmj.3.5667.390

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