Tissue catecholamine concentrations in spontaneously hypertensive rats.

B Wocial; J Chodakowska; Z Zukowska-Grójec; M Rutczyński; W Boratyński

PubMed · 596180

Tissue catecholamine concentrations in spontaneously hypertensive rats.

B Wocial·J Chodakowska·Z Zukowska-Grójec·M Rutczyński·W Boratyński

Abstract

Tissue concentrations of noradrenaline (NA), dopamine (DA) and adrenaline (A) were compared in spontaneously hypertensive (SHR) and normotensive (NCR) rats, aged 1, 3, 8, 14 and 24 weeks The organs analyzed included the brain, subdivided into prosencephalon and rhombencephalon, heart, adrenal glands and kidney. Brain catecholamines were significantly lower in SHR than in NCR, and the difference appeared already at the age of 3 weeks. Concomitant increase was found in the adrenal NA and A concentrations of the SHR. Concentration of NA in the heart decreased in the SHR following onset of hypertension. It is concluded that the diminished NA, DA and A concentrations in the brain as well as the augmented adrenal NA and A levels in the SHR may be causally related to the development of hypertension, while the heart NA level reflects the secondary, hypertension -- related changes.

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Adrenal Glands Animals Blood Pressure Brain Chemistry Catecholamines Disease Models, Animal Dopamine Epinephrine Heart Rate Hypertension Kidney Myocardium Norepinephrine Rats Rats, Inbred Strains Journal Article

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B Wocial, J Chodakowska, Z Zukowska-Grójec, M Rutczyński, W Boratyński. Tissue catecholamine concentrations in spontaneously hypertensive rats.. https://pubmed.ncbi.nlm.nih.gov/596180/

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