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PubMed · 6271842

Cannabinoids in glaucoma: a primary screening procedure.

M A Elsohly·E Harland·J C Murphy·P Wirth·C W Waller
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Abstract

A procedure was developed for screening of cannabinoids for their ability to reduce intraocular pressure (IOP) using normal rabbits. Eight animals per group were used for statistical significance of data. A negative control group was used for every screen as well as a positive control with 1.5 mg/kg delta 9-THC given intravenously (I.V.). All compounds were tested by I.V. injection and IOP measurements were taken periodically for 5 hours. Data were analyzed by a computer program which takes into account the change in IOP of the control group. Following this procedure we found that delta 8-THC, delta 9-THC, cannabinol, and nabilone were active while cannabidiol was inactive.

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AnimalsCannabidiolCannabinoidsCannabinolDronabinolDrug Evaluation, PreclinicalFemaleGlaucomaIntraocular PressureMaleRabbitsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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M A Elsohly, E Harland, J C Murphy, P Wirth, C W Waller. Cannabinoids in glaucoma: a primary screening procedure.. https://doi.org/10.1002/j.1552-4604.1981.tb02627.x

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