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PubMed · 6285709

Acyclovir tolerance in humans.

R E Keeney·L E Kirk·D Bridgen
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Abstract

Acyclovir tolerance has been explored in a broad range of human populations and dosage regimens with intravenous, topical, and oral formulations. Phase I pharmacokinetic/tolerance studies assured safety in special populations at unique risk of complicated herpes infections who were simultaneously at increased risk of toxicity to anti-DNA chemotherapeutic agents. Further safety evaluations accompanied placebo-controlled Phase II studies in infected patients who represent future users of acyclovir. These studies confirm acyclovir as the safest antiherpes agent to be explored in clinical studies to date.

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AcyclovirAdultAntiviral AgentsBone Marrow TransplantationChildChild, PreschoolCreatinineDrug EvaluationFemaleGuanineHerpes GenitalisHerpes SimplexHerpesviridae InfectionsHumansInfantInfant, NewbornKidney TransplantationMaleJournal Article

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BibTeXRIS

R E Keeney, L E Kirk, D Bridgen. 1982-07-20. Acyclovir tolerance in humans.. https://doi.org/10.1016/0002-9343(82)90086-9

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