Estimation of thresholds for evoked potentials using a laboratory computer.

D M Wilkison

doi:10.1016/0165-0270(83)90007-9

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Estimation of thresholds for evoked potentials using a laboratory computer.

D M Wilkison

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Abstract

To study drug effects on bioelectric activity evoked by near-threshold stimulation, we have developed a computerized threshold estimation technique. The procedure utilizes a laboratory computer (PDP 11/34) equipped with a standard laboratory interface with A/D and D/A capabilities. Program-controlled voltage pulses, delivered via D/A, are interfaced through a constant current stimulus isolation unit for electrical stimulation. One channel of activity is digitized at a user-defined rate and the signal is searched for a response. Responses were generally defined by a feature of the signal which was greater than a multiple of its standard deviation in the subthreshold signal. Using some a priori knowledge of the expected response and user-defined processing options, the program determines threshold on-line without pretrial test data. Program operation is illustrated with sensory evoked potentials in acutely prepared cats and hippocampal evoked potentials in chronically implanted rats.

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Animals Cats Computers Electric Stimulation Evoked Potentials, Somatosensory Evoked Potentials, Visual Hippocampus Neural Pathways Neurophysiology Optic Chiasm Radial Nerve Sensory Thresholds Software Somatosensory Cortex Synaptic Transmission Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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D M Wilkison. 1983. Estimation of thresholds for evoked potentials using a laboratory computer.. https://doi.org/10.1016/0165-0270(83)90007-9

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