PubMed HealthSearch

PubMed · 6370218

Topical corticosteroids.

Abstract

Topical corticosteroid therapy has revolutionised the management of many dermatological disorders. While treatment usually is effective there are problems associated with inappropriate therapy. This article reviews the availability and use of topical corticosteroid preparations in the treatment of common dermatological conditions.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J Gambrill, L Miller. 1984. Topical corticosteroids.. https://pubmed.ncbi.nlm.nih.gov/6370218/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Topical interleukin 1 receptor antagonist promotes corneal transplant survival.

BACKGROUND: Interleukin (IL)-1 is a potent proinflammatory cytokine that plays a critical role in initiating and maintaining immunogenic inflammation. We performed a series of experiments to determine whether the topical application of IL-1 receptor antagonist (IL-1ra) can prolong corneal transplant survival in the murine model of orthotopic allotransplantation. METHODS: For all experiments, C57BL/6 corneas were transplanted into BALB/c (major histocompatibility and minor histocompatibility-disparate) eyes. "High-risk" transplants were transplants that had been sutured into BALB/c recipient beds with corneal neovascularization induced by placement of three interrupted sutures in the host cornea 2 weeks earlier. Both risk groups were divided in a masked fashion into treatment subgroups that received either 20 mg/ml of IL-1ra mixed in 0.2% sodium hyaluronate vehicle (n=28) or placebo alone (n=25). All transplants were evaluated for 8 weeks after surgery for signs of rejection. At the end of follow-up, corneal specimens were processed for enumeration of Langerhans cells and histopathological evaluation. RESULTS: Survival rates of both normal-risk and high-risk transplants increased significantly among the IL-1ra-treated animals compared with untreated controls by both stratified Mantel-Haenszel (P=0.02) and Kaplan-Meier survival (P=0.03) analyses. Furthermore, both normal- and high-risk IL-1ra-treated grafts had significantly less inflammation and Langerhans cells infiltration compared with untreated controls. CONCLUSIONS: Topical treatment with IL-1ra has a significantly positive effect in promoting corneal allograft survival.

Administration, Topical

The effect of topical turpentine on the functional properties of cutaneous afferents in the anaesthetized rat.

Turpentine was applied to the rat dorsal hindpaw over 1.5-3.5 h and afferent activity was recorded for 1.5-7 h after its removal. Increased spontaneous activity from both A- and C-fibres was observed. There was an increase in units with no response to natural stimuli and a reduction in the numbers of all types of afferent unit, with some recovery of the C- and A delta-classes during the recording period. Surviving C-polymodal nociceptor units had normal sensitivity to noxious heat, but higher mechanical thresholds. Thus turpentine application caused no nociceptor sensitization. Instead, the many insensitive units plus the generalized spontaneous firing may be signs of non-specific axonal damage. A general division of irritant chemicals into those that are predominately damaging, like turpentine, and those that generate specific nociceptor firing or sensitization, is proposed.

Administration, Topical