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Intraventricular chloramphenicol.

J H Salmon
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Abstract

Very high intraventricular chloramphenicol levels can be obtained if the standard systemic dose is supplemented with a small intraventricular dose. Chloramphenicol sodium succinate can be hydrolyzed to the microbiologically active chloramphenicol in the ventricular fluid. Daily injections are ordinarily adequate to maintain a high concentration of antibiotic. Initial dosage should vary with ventricular volume. The brain does not tolerate repeated needle puncture and the use of a ventriculostomy reservoir is recommended.

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AnimalsChloramphenicolDogsHumansHydrocephalusInfantInfant, NewbornInfant, Newborn, DiseasesInjections, IntraventricularMeningitisJournal Article

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J H Salmon. 1978. Intraventricular chloramphenicol.. https://doi.org/10.1159/000119767

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