PubMed · 6397495
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A Yoshinaga, Y Kojo, Y Hamada. 1984. Irregularly distributed varicella.. https://doi.org/10.1111/j.1346-8138.1984.tb01514.x
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BACKGROUND: Burn injuries trigger complex immune responses and gene expression changes, impacting wound healing and systemic inflammation. Understanding these changes is crucial for identifying biomarkers and therapeutic targets. METHODS: We analyzed two gene expression omnibus datasets (wound tissue [GSE8056] and blood [GSE37069]) to identify differentially expressed genes (DEGs) in burn injury samples versus controls. Immune cell proportions were assessed using CIBERSORT. Functional enrichment analyses (Gene Ontology and Kyoto Encyclopedia of Genes and Genomes) and protein-protein interaction networks were constructed to identify key genes and pathways. RESULTS: We identified 1170 upregulated and 1227 downregulated DEGs. Gene Ontology analysis revealed enrichment in neutrophil activation, inflammatory response, and extracellular matrix organization. Kyoto Encyclopedia of Genes and Genomes analysis highlighted cytokine-cytokine receptor interaction, TNF, and IL-17 signaling pathways. Immune infiltration analysis showed significant changes in neutrophils, macrophages (M1/M2), and T-cell subsets. Protein-protein interaction network analysis identified five hub genes: JUN, STAT1, Bcl2, MMP9, and TLR2. CONCLUSIONS: This study provides a comprehensive bioinformatic analysis of gene expression and immune responses in burn injuries. The identified DEGs, hub genes, and pathways offer insights into the immune response mechanisms and suggest potential targets for diagnostic and therapeutic interventions in burn injury management.
In India, isolated burns of the feet in children are common, but people seldom seek specialized treatment. These burns result from careless disposal of hot ash or embers after cooking or religious functions. Five children were treated for acute burns of the feet, with tangential excision and skin grafting. Early surgical treatment of these seemingly innocuous burns offers distinct advantages, i.e., avoidance of painful dressings, the need for reconstructive procedures, and reduced hospital stay. It also helps in early return to childhood activities and normal growth of the foot. A new concept of excising deep dermal burns of the "sole" is emphasized to preserve sensate unburned dermis.
A possible major etiology is presented for previously unexplained throat and oral ulceration, inflammation and scarring, and also tissue loss associated with dental implant fixtures, oral surgery and periodontal flaps, and diffuse facial and pulpal pain. A simple solution is suggested.