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PubMed · 6450711

[Expanded model of lambda phage ontogeny].

G Kh Kananian·V A Ratner·R N Churaev
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Abstract

An enlarged threshold model of regulatory system of development of lambda phage (RSDP lambda-2) is built. It includes 15 synthetic blocks of proteins and mRNAs and 4 blocks corresponding to the ontogenetic processes: two-stage replication, integration and exclusion of phage genome, formation of aggregates of regulatory proteins, regulation of bacterial lysis. By means of computer simulation of the RSDP lambda-2 model, the dynamics of concentrations of all main proteins, respective fractions of mRNAs and DNA are described in lytic and lysogenic regimens of phage ontogenesis. The results obtained are in a good agreement with available experimental data. The dependence of portion (%) of lysogenic responses on the mean multiplicity n of phage infection of bacterial culture, is built. This curve has a maximum point in accordance with experimental data of Kourilsky [10].

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Bacteriophage lambdaComputersGenes, RegulatorGenes, ViralLysogenyMathematicsModels, GeneticRNA, MessengerRNA, ViralViral ProteinsEnglish AbstractJournal Article

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G Kh Kananian, V A Ratner, R N Churaev. 1980. [Expanded model of lambda phage ontogeny].. https://pubmed.ncbi.nlm.nih.gov/6450711/

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