Suppressor cell dysfunction and necrotizing lesions in a child.

S J McGeady; O Buella; R Heimer; H C Mansmann

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PubMed · 6451200

Suppressor cell dysfunction and necrotizing lesions in a child.

S J McGeady·O Buella·R Heimer·H C Mansmann

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Abstract

A girl had opportunistic infections and was found to have T-cell dysfunction. During a period of months, recurrent staphylococcal infections, polyclonal hyperglobulinemia, eosinophilia, and peripheral, necrotizing, cutaneous lesions developed. Circulating immune complexes were demonstrated, and abnormal suppressor-cell function was found. At age 36 months, the child died of a staphylococcal pneumonia. At postmortem examination, the thymus gland was found to be histologically abnormal, lacking corticomedullary differentiation. We propose that this patient had a syndrome in which lymphocyte abnormalities and dysfunction of suppressor T cells permitted hyperresponsiveness of antibody-forming cells. Large amounts of circulating antibody and immune complexes were formed, and their deposition led to peripheral tissue injury.

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Antigen-Antibody Complex Female Humans Immunologic Deficiency Syndromes Infant Lymphocytes Necrosis Skin Staphylococcal Infections T-Lymphocytes, Regulatory Case Reports Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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S J McGeady, O Buella, R Heimer, H C Mansmann. 1981. Suppressor cell dysfunction and necrotizing lesions in a child.. https://pubmed.ncbi.nlm.nih.gov/6451200/

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