[Decrease in the intensity of the EPR cytochrome P-450, adrenodoxine and free radical signals in the adrenal cortex of dogs under the effect of o,p-dichlorodiphenyldichloroethane].

A S Mikosha; N N Berezovskaia

PubMed · 6647432

[Decrease in the intensity of the EPR cytochrome P-450, adrenodoxine and free radical signals in the adrenal cortex of dogs under the effect of o,p-dichlorodiphenyldichloroethane].

Abstract

A study was made of the action of the adrenocorticolytic drug chloditane (o.p'-DDD) on the content of cytochrome P-450 adrenodoxine and free radicals in the dog adrenal cortex. After a single feeding of 50 mg/kg bw o.p'-DDD EPR signals with xi-factors 2.25, 1.94 and 2.00 reduced 30-40%. Three-fold feeding of the drug in a dose of 100 mg/kg bw produced a further demonstrable decrease of signals. These changes attest to a possible inhibition of the hydroxylase complex in the adrenal cortex induced by o.p'-DDD.

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Adrenal Cortex Adrenodoxin Animals Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System Dogs Dose-Response Relationship, Drug Free Radicals Male Mitotane English Abstract Journal Article

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A S Mikosha, N N Berezovskaia. [Decrease in the intensity of the EPR cytochrome P-450, adrenodoxine and free radical signals in the adrenal cortex of dogs under the effect of o,p-dichlorodiphenyldichloroethane].. https://pubmed.ncbi.nlm.nih.gov/6647432/

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