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An efficient method for labelling antibodies with 111In.

R G Buckley·F Searle
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Abstract

Using a new method, rabbit IgG and a monoclonal antibody have been conjugated with the chelating agent DTPA. This was accomplished with reaction conditions that should entail lower antibody damage than existing methods. Gel filtration of the 111In-labelled antibody conjugate indicated minimal damage to the antibody and radioimmunoassay showed no significant change in its immunological activity.

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AntibodiesChelating AgentsChemical PhenomenaChemistryIndiumPentetic AcidRadioimmunoassayRadioisotopesJournal ArticleResearch Support, Non-U.S. Gov't

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R G Buckley, F Searle. 1984-01-23. An efficient method for labelling antibodies with 111In.. https://doi.org/10.1016/0014-5793(84)80073-3

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