Adaptation to hyperosmolality in the rat.

A H Lockwood

doi:10.1016/0006-8993(80)91112-9

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Adaptation to hyperosmolality in the rat.

A H Lockwood

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Abstract

Hyperosmolality induced in rats results in a progressive increase in brain glutamine levels with out a change in ammonia. This suggests an adaptation in the compartmental nature of the glutamate-ammonia-glutamine metabolic system to provide more brain osmoles without excess ammonia. The brain: blood glucose ratio rose suggesting brain energy use rate reductions previously reported may be due to altered glucose transport or phosphorylation.

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Acclimatization Acid-Base Imbalance Amino Acids Animals Bicarbonates Blood Brain Carbon Dioxide Glucose Glutamine Hydrogen-Ion Concentration Male Osmolar Concentration Rats Journal Article Research Support, U.S. Gov't, P.H.S.

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A H Lockwood. 1980-10-27. Adaptation to hyperosmolality in the rat.. https://doi.org/10.1016/0006-8993(80)91112-9

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