PubMed · 6965056
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
J P Loreille, A Bery. 1982. [Does intermaxillary disjunction increase nose breathing?].. https://pubmed.ncbi.nlm.nih.gov/6965056/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
1. The mechanisms of vascular adaptation to pregnancy remain to be fully elucidated. In this study we have compared flow-induced dilatation and myogenic responses in fifth generation mesenteric arteries from late pregnant and non-pregnant Wistar rats. 2. Myogenic tone, assessed as the difference between internal diameter (i.d.) in the presence and absence of external calcium, at each of six transmural pressure steps (40-90 mmHg) was no different in arteries from pregnant and non-pregnant animals (90 mmHg; pregnant animals, 20.5 +/- 3.2% change in i.d., n = 13; non-pregnant animals, 14.4 +/- 4.4% change in i.d., n = 13; n.s.). 3. Flow-induced dilatation was significantly increased in arteries from pregnant animals when compared with that in non-pregnant animals (pregnant, 11.2 +/- 3.7% increase in i.d., n = 12; non-pregnant, 1.2 +/- 1.0%, n = 8; P < 0.02; at the maximal flow rate of 1.46 microliters s-1). 4. Flow-induced dilatation was significantly reduced in arteries from pregnant rats after incubation with the nitric oxide synthase inhibitor N omega-nitro-L-arginine methyl ester (11.2 +/- 3.7% increase in i.d. vs. 0.8 +/- 1.5% with L-NAME, n = 12, at a flow rate of 1.46 microliters s-1; P < 0.02), but not altered in non-pregnant rats (1.2 +/- 1.0% vs. 1.4 +/- 1.5% with L-NAME, n = 8; n.s.). This was also reflected in a greater response to shear stress in the arteries from pregnant animals. 5. We conclude that myogenic tone is not significantly different in pregnant and non-pregnant resistance sized mesenteric arteries of Wistar rats. However, flow-induced dilatation, mediated by nitric oxide release, may play a major role in lowering vascular resistance during pregnancy.
To clarify which hemodynamic measurement correlates best with lung mechanics in infants with congenital heart disease and left-to-right shunts, dynamic pulmonary function tests and echocardiography were performed in 26 infants with such disease (study infants) and in 37 normal, healthy infants (control infants). The tidal volume and pulmonary compliance (CL) were lower and airway resistance higher in infants with congenital heart disease than in control infants. A significant correlation was demonstrated between CL, expiratory resistance (Re), and the right pulmonary artery-to-aortic size ratio (RPA/DAO). CL and Re also correlated well with the corrected acceleration time square root of RR ratio (ACT/square root of RR: ACT, acceleration time and RR: length of the cardiac cycle) of pulmonary flow velocity. Stepwise multiple regression analysis revealed that RPA/DAO correlated best with both CL and Re. It is concluded that infants with congenital heart disease and left-to-right shunts have lower lung compliance and higher expiratory airway resistance than normal children, and that RPA/DAO is the echocardiographic parameter that correlates best with the changes in lung mechanics.
The role of nebulized flunisolide solution in controlling recurrent respiratory symptoms was assessed in a double-blind placebo-controlled parallel study on 23 infants and small children (mean age, 14.2 months) with bronchial asthma. Five of the 12 children in the placebo group and 1 of the 11 patients on active treatment had to be withdrawn from the study. Flunisolide significantly improved symptom scores of wheezing and cough. The rescue treatments with salbutamol did not differ between the two groups during the study. Parents considered the active treatment effective in all the patients, while the placebo was considered useful in 4 of 7 children. No side effects were detected with either treatments. This study indicates that nebulized flunisolide may be an effective treatment for infants with recurrent wheezing and cough.