Effects of cortisone on decrease of serum albumin secondary to experimental infections.

M Deysine; N Leiblich; R Rubenstein; E Rosario

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PubMed · 6998026

Effects of cortisone on decrease of serum albumin secondary to experimental infections.

M Deysine·N Leiblich·R Rubenstein·E Rosario

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Abstract

The observation that severe clinical bacterial infections are associated with decreases in total serum albumin levels was confirmed in experiments involving dogs and rats. In rodents, the injection of methylprednisolone sodium succinate after the onst of the infection significantly reduced the decrease in the serum albumin values. However, this protective or corrective effect did not occur if the steroid was given prior to the infection. The effect of cortisone may be due to its capacity to stimulate albumin synthesis by the parenchyma of the liver.

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Animals Cortisone Disease Models, Animal Dogs Escherichia coli Infections Female Male Methylprednisolone Hemisuccinate Rats Sepsis Serum Albumin Shock, Septic Journal Article

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M Deysine, N Leiblich, R Rubenstein, E Rosario. 1980. Effects of cortisone on decrease of serum albumin secondary to experimental infections.. https://pubmed.ncbi.nlm.nih.gov/6998026/

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