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A computerized model to analyze transcellular fluid shift during hemofiltration.

G Kimura·M Satani·S Kojima·K Kuroda·K Itoh·M Ikeda
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Abstract

Using urea and inulin as markers, we have developed a simple method to calculate intracellular and extracellular fluid volume in patients before and after hemofiltration therapy. During conventional hemofiltration using substitution fluid with a Na+ concentration of 140 mEq/L, a decrease in extracellular fluid volume was noted whereas the intracellular fluid volume was unaltered. Furthermore, we have developed a computerized mathematical model to analyze transcellular fluid shifts during hemofiltration. This model also indicates a decrease in extracellular fluid volume only, the intracellular fluid volume remaining unchanged. High-Na+ hemofiltration using substitution fluid with an Na+ concentration of 160 mEq/L has enabled us to remove fluid from both intracellular and extracellular compartments. Thus, high-Na+ hemofiltration is expected to normalize the intracellular hydration in uremic patients, and to reduce the decrease in extracellular fluid volume during hemofiltration therapy. Our data therefore suggest that high-Na+ hemofiltration could prevent hypotension due to large decreases in extracellular fluid volume by inducing a transcellular fluid shift out of body cells. Our computerized model can be a useful tool in the prescription of the optimal Na+ concentration in substitution fluid for individualized hemofiltration therapy.

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AdultBiological TransportBloodBody FluidsComputersExtracellular SpaceFemaleHumansIntracellular FluidMathematicsModels, BiologicalSodiumUltrafiltrationJournal Article

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G Kimura, M Satani, S Kojima, K Kuroda, K Itoh, M Ikeda. 1982. A computerized model to analyze transcellular fluid shift during hemofiltration.. https://doi.org/10.1111/j.1525-1594.1982.tb04054.x

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