[Thromboresistant properties of polyelectrolyte complexes based on weak polyelectrolytes].

A K Chepurov; N C Makhortov; N K Zimin; A A Iudin; V N Eremin

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PubMed · 7267466

[Thromboresistant properties of polyelectrolyte complexes based on weak polyelectrolytes].

A K Chepurov·N C Makhortov·N K Zimin·A A Iudin·V N Eremin

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Abstract

Thrombogenic resistant polyelectrolyte compositions were obtained on the basis of weak polyelectrolytes used in different quantity proportions. The investigations were performed in vitro on rabbit blood and in vivo on 21 dogs and 5 calves in the conditions of acute and chronic experiments. The optimal compositions of polymers were selected for the implantation. The appropriate polyelectrolyte compositions on the basis of weak polyelectrolytes, and polymers modified by polyacryl acid with polyethylene piperazine (1:1, 2:1, 3:1), were found to be thrombogenic resistant and did not cause any significant blood cells damage. The investigations performed the possibility for their practical application.

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Animals Aorta, Abdominal Biocompatible Materials Blood Vessel Prosthesis Cattle Chemical Phenomena Chemistry Dogs Drug Evaluation, Preclinical Fibrinolytic Agents Iliac Artery In Vitro Techniques Platelet Aggregation Polymers Rabbits Thrombosis Comparative Study English Abstract Journal Article

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A K Chepurov, N C Makhortov, N K Zimin, A A Iudin, V N Eremin. 1980. [Thromboresistant properties of polyelectrolyte complexes based on weak polyelectrolytes].. https://pubmed.ncbi.nlm.nih.gov/7267466/

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