PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 7272006

Serum protein polymorphisms in goitre.

J K Gupta·D N Bhardwaj·H Kaur·P K Shrivastava
View original source ↗Export metadata ↓

Abstract

Serum albumin, ceruloplasmin, transferrin and haptoglobin were studied in 50 patients with both toxic and non-toxic forms of goitre. Albumin was monomorphic in all cases and its amount was substantially lower than normal in two patients. Ceruloplasmin was both qualitatively and quantitatively normal in all patients. No genetic variants of transferrin were encountered but 22% of the patients had this protein, at levels barely detectable by electrophoretic means. Such cases of hypotransferrinaemia occurred oftener in patients with the toxic form of goitre than in those with the non-toxic one. The distribution of haptoglobin types in patients was much the same as in the control blood donors. However, the patients had a greater incidence of ahaptoglobinaemia.

Explore related subjects

Blood Protein ElectrophoresisBlood ProteinsCeruloplasminGoiterHaptoglobinsHemoglobinsHumansPolymorphism, GeneticSerum AlbuminTransferrinJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J K Gupta, D N Bhardwaj, H Kaur, P K Shrivastava. 1981. Serum protein polymorphisms in goitre.. https://pubmed.ncbi.nlm.nih.gov/7272006/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

[Monoclonal gammopathies of undetermined significance].

Monoclonal gammopathies of undetermined significance constitute a body of asymptomatic diseases characterized by a selective increase of a single serum immunoglobulin due to an only dysregulated clone of B lymphocytes. They occur in up to 10% of persons over 80 years of age. The diagnosis is suggested in presence of both M component in serum <30 g/L and bone marrow plasma cells <10% by the exclusion of multiple myeloma or lymphoproliferative disorders. In most MGUS, however, populations of normal and myelomatous plasma cells coexist in a stable ratio. The overall relative risk for progression is 7 times the expected rate, depending from the disease and the type of M component.

Blood Protein Electrophoresis↗
PubMed2006

[A rare cause of diffuse pulmonary hemorrhage in a 45 year-old man].

Diffuse pulmonary hemorrhage denotes a diffuse bleeding into the alveoli as a result of severe damage of the alveolocapillary membrane. Autoimmune diseases, toxic injury and hemodynamic changes are the most frequent causes. A 45 year old male patient presented with diffuse alveolar hemorrhage. An Immunoglobulin A (IgA) paraprotein secreting myeloma was found to be the underlying cause. Immunohistochemistry revealed dense pericapillary and perivascular deposits of IgA, indicating a paraprotein mediated damage of the alveolocapillary membrane. The predominantly vascular pattern of damage was regarded as the most likely cause of the pulmonary hypertension in this patient. The diffuse pulmonary bleeding stopped after initiation of treatment consisting of vincristine, adriamycine and dexamethasone.

Blood Protein Electrophoresis↗