Matrix algebraic simulation of mitotic cell selection experiments.

S P Tomasovic; J L Roti Roti; L A Dethlefsen

doi:10.1111/j.1365-2184.1980.tb00455.x

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Matrix algebraic simulation of mitotic cell selection experiments.

S P Tomasovic·J L Roti Roti·L A Dethlefsen

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Abstract

Mitotic cell selection experiments are frequently utilized in investigations on the effects of various metabolic inhibitors and/or X-irradiation on cell-cycle progression of mammalian cells in tissue culture. This study describes a method for matrix algebraic simulation of these experiments which involves the sequential multiplication of cell-population matrices, growth matrices, and mitotic cell-selection matrices. Simulations are shown for progression in control cultures and cultures perturbed either by X-rays or 2-mercapto-1(beta-4-pyridethyl) benzimidazole. Application of this model will enhance the planning of these investigations and allow more rigorous testing of alternate hypotheses concerning the mechanisms of action of perturbing agents.

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Animals Benzimidazoles Cell Cycle Cell Line Cell Separation Computers Cricetinae Female Mathematics Mitosis Models, Biological Ovary Pyridines X-Rays Journal Article Research Support, U.S. Gov't, P.H.S.

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S P Tomasovic, J L Roti Roti, L A Dethlefsen. 1980. Matrix algebraic simulation of mitotic cell selection experiments.. https://doi.org/10.1111/j.1365-2184.1980.tb00455.x

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