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Dissolution test method for rifampicin-isoniazid fixed dose formulations.

K C Jindal·R S Chaudhary·A K Singla·S S Gangwal·S Khanna
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Abstract

A dissolution procedure for a rifampicin-isoniazid combination formulation was evaluated using 0.1 N hydrochloric acid solution and 0.4% (w/v) sodium lauryl sulphate solution as dissolution media. Rifampicin and isoniazid along with degradation components were chromatographed using reversed-phase liquid chromatography on a 10 microns octadecylsilica column using methanol-0.01 M disodium hydrogen phosphate (70:30, v/v; pH 4.6 +/- 0.1) as mobile phase. The detection was carried out at 254 nm. The data obtained indicate that the dissolution medium consisting of 0.4% (w/v) sodium lauryl sulphate solution is suitable for such a combination. The degradation observed in dissolution medium consisting of 0.1 N hydrochloric acid was 10-23%.

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CapsulesChromatography, High Pressure LiquidDrug CombinationsHumansIndicators and ReagentsIsoniazidRifampinSolubilitySpectrophotometry, UltravioletJournal Article

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K C Jindal, R S Chaudhary, A K Singla, S S Gangwal, S Khanna. 1994. Dissolution test method for rifampicin-isoniazid fixed dose formulations.. https://doi.org/10.1016/0731-7085(94)80030-8

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