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Physical effort-induced changes in immune parameters.

L Grazzi·A Salmaggi·A Dufour·C Ariano·A M Colangelo·E Parati·M Lazzaroni·A Nespolo·G Bordin·C Castellazzi
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Abstract

Physical stress induces changes in immune system parameters; these changes depend on effort schedule and are influenced by customary training. The mechanisms whereby they take place are not fully elucidated: sympathetic activation-mediated mobilization of cells of lymphoid organs, including the spleen, has been suggested. We studied exercise-induced changes (20' of cycloergometer test conducted up to 80% of maximal expected heart rate) in white blood cells (WBC), lymphocyte subsets, plasma catecholamine and cortisol levels in three groups of subjects: swimmers, untrained controls and splenectomized individuals. Physical exercise induced increase of WBC and significant changes in the percentage of most investigated lymphocyte subsets (NK, CD3+, CD4+, CD8+ and CD4/CD8 ratio), except for DR+ cells. No changes occurred in the percentage of CD14+ cells. Norepinephrine (NE) levels increased after effort, while epinephrine (E) and cortisol levels were unchanged. Splenectomized patients displayed similar effort-induced changes in investigated parameters as controls and swimmers. The results support the interactions between physical work and immune response and minimize the role of the spleen in this context.

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AdultAntigens, CDCatecholaminesHeart RateHumansHydrocortisoneImmunityImmunoglobulin MLymphocytesMaleSpleenSplenectomyWorkComparative StudyJournal Article

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L Grazzi, A Salmaggi, A Dufour, C Ariano, A M Colangelo, E Parati, M Lazzaroni, A Nespolo, G Bordin, C Castellazzi. 1993. Physical effort-induced changes in immune parameters.. https://doi.org/10.3109/00207459308994268

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